Cancer Letters 2011-12-15

Identification of tumoral glial precursor cells in neuroblastoma.

Sandra Acosta, Gemma Mayol, Eva Rodríguez, Cinzia Lavarino, Katleen de Preter, Candy Kumps, Idoia Garcia, Carmen de Torres, Jaume Mora

文献索引：Cancer Lett. 312(1) , 73-81, (2011)

全文：HTML全文

摘要

Neuroblastic tumors (NBT) are composed by neuroblasts and Schwannian-like stroma. The origin of these two cell subtypes remains unclear. In this study, we describe, a neuroblastic-like subpopulation in neuroblastoma (NB) coexpressing GD2 and S100A6, neuroblastic and glial lineage markers respectively. The GD2(+)/S100A6(+) neuroblastic subpopulation was found to be enriched in low risk NB, distributed around the perivascular niche. Some stromal bundles showed GD2(+)/S100A6 costaining. Metastatic bone marrow specimens also showed GD2(+)/S100A6(+) cells. During in vitro retinoic acid induced differentiation of NB cell lines, rare GD2(+)/S100A6 neuroblatic cells appeared. We conclude that GD2(+)/S100A6(+) neuroblasts may represent a tumoral glial precursor subpopulation in NBT.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.