Bioorganic & medicinal chemistry letters

Synthesis, structure analysis, and antitumor activity of 3, 6-disubstituted-1, 4-dihydro-1, 2, 4, 5-tetrazine derivatives

GW Rao, WX Hu

文献索引：Rao, Guo-Wu; Hu, Wei-Xiao Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3702 - 3705

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被引用次数: 59

摘要

Fourteen compounds of 3, 6-disubstituted-1, 4-dihydro-1, 2, 4, 5-tetrazine derivatives were prepared and their structures were confirmed by single-crystal X-ray diffraction and the semi- empirical calculation of PM3 method. This reaction yields the 1, 4-dihydro derivatives rather than the 1, 2-dihydro derivatives. The central six-membered ring of 1, 4-dihydro-1, 2, 4, 5- tetrazine has a chair conformation and therefore is not homoaromatic. Their antitumor ...