Molecules

An improved synthesis of some 5-substituted indolizines using regiospecific lithiation

AG Kuznetsov, AA Bush, VB Rybakov, EV Babaev

文献索引：Kuznetsov, Alexey G.; Bush, Alexander A.; Rybakov, Viktor B.; Babaev, Eugene V. Molecules, 2005 , vol. 10, # 9 p. 1074 - 1083

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被引用次数: 15

摘要

Abstract: Various 2-substituted indolizines can be directly and selectively lithiated in the 5 position and subsequent reactions with different electrophiles lead to some novel classes of indolizines. In particular, previously unknown 5-formyl-and 5-iodoindolizine have been prepared by this way and the molecular structure of 5-formyl-2-phenylindolizine was confirmed by X-Ray analysis. The reactivity of the 5-CHO-and 5-COPh groups toward ...