Abstract The potent antibiotic thiazolylpeptide GE2270 A was synthesized starting from N- tert-butyloxycarbonyl protected valine in a longest linear sequence of 20 steps and with an overall yield of 4.8%. Key strategy was the assembly of the 2, 3, 6-trisubstituted pyridine core by consecutive cross-coupling reactions starting from 2, 6-dibromo-3-iodopyridine. The complete Southern fragment was installed by Negishi cross-coupling of 3-zincated 2, 6- ...
