Journal of Medicinal Chemistry 2004-03-25

7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.

Diane H Boschelli, Yanong D Wang, Steve Johnson, Biqi Wu, Fei Ye, Ana Carolina Barrios Sosa, Jennifer M Golas, Frank Boschelli

文献索引：J. Med. Chem. 47(7) , 1599-601, (2004)

全文：HTML全文

摘要

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.