Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1

R De Simone, I Bruno, R Riccio, K Stadler…

文献索引：De Simone, Rosa; Bruno, Ines; Riccio, Raffaele; Stadler, Katharina; Bauer, Julia; Schaible, Anja M.; Laufer, Stefan; Werz, Oliver Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5012 - 5016

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被引用次数: 9

摘要

Microsomal prostaglandin E2 synthase-1 (mPGES-1) has been recognized as novel, promising drug target for anti-inflammatory and anticancer drugs. mPGES-1 catalyzes the synthesis of the inducible prostaglandin E2 in response to pro-inflammatory stimuli, rendering this enzyme extremely interesting in drug discovery process owing to the drastic reduction of the severe side effects typical for traditional non-steroidal anti-inflammatory ...