前往化源商城

Synthesis

Enantioselective synthesis of substituted 3-quinolyl alkanols and their application to asymmetric autocatalysis

I Sato, T Nakao, R Sugie, T Kawasaki, K Soai

文献索引:Sato, Itaru; Nakao, Tomohiko; Sugie, Rie; Kawasaki, Tsuneomi; Soai, Kenso Synthesis, 2004 , # 9 p. 1419 - 1428

全文:HTML全文

被引用次数: 10

摘要

Here we report enantioselective syntheses of 2-, 5-, 6-, 7- and 8-substituted 3-quinolyl alkanols and their asymmetric autocatalytic reactions in the enantioselective addition of diisopropylzinc to the corresponding substituted quinoline-3-carbaldehydes (Scheme [1] ). Highly enantiomerically enriched 3-quinolyl alkanols with up to 97% ee were obtained by asymmetric autocatalysis. ... Scheme 1 Asymmetric autocatalysis of 5-, 6-, 7-, 8-substituted 3-quinolyl alkanol.