Chemistry–A European Journal

An Efficient Enzymatic Synthesis of Benzocispentacin and Its New Six??and Seven??Membered Homologues

E Forró, F Fülöp

文献索引：Forro, Eniko; Fueloep, Ferenc Chemistry - A European Journal, 2006 , vol. 12, # 9 p. 2587 - 2592

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被引用次数: 33

摘要

Abstract A very efficient enzymatic method was developed for the synthesis of new enantiomeric benzocispentacin and its six-and seven-membered homologues through the Lipolase (lipase B from Candida antarctica) catalyzed enantioselective (E> 200) ring opening of 3, 4-benzo-6-azabicyclo [3.2. 0] heptan-7-one, 4, 5-benzo-7-azabicyclo [4.2. 0] octan-8-one, and 5, 6-benzo-8-azabicyclo [5.2. 0] nonan-9-one with H 2 O in iPr 2 O at 60 ...