2, 4-Diaminopyrimidines as antimalarials. II. 5-Benzyl derivatives

EA Falco, S DuBreuil, GH Hitchings

文献索引：Falco et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3758,3760

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被引用次数: 33

摘要

The discovery of antimalarial activity in 5-(4'-chlorophenoxy)-2, 4-diaminopyrimidine1 and its 6-methyl homol~ g~~~ indicated the desirability of the preparation and testing of various related structures. The oxygen atom of the phenoxypyrimidine was viewed as a connecting group of unknown importance between the pyrimidine and benzene nuclei. The preparation of similar substances with various atoms and groups, including nitrogen, sulfur and carbon ...