Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1, 8-naphthalimide derivatives

…, S Ding, J Zhang, S Wang, G Zhou, C Zhou, X Li

文献索引：Li, Shenghui; Xu, Shengjie; Tang, Yonghe; Ding, Shan; Zhang, Jinchao; Wang, Shuxiang; Zhou, Guoqiang; Zhou, Chuanqi; Li, Xiaoliu Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 586 - 590

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被引用次数: 9

摘要

Abstract A novel series of 4-pyrazolyl-1, 8-naphthalimide derivatives have been designed and facilely synthesized. For anticancer activity in vitro, most of the compounds were found to be more toxic against human mammary cancer cells (MCF-7) than human cervical carcinoma cells (Hela) and human lung cancer cells (A549). Compounds 4i, 4h, 4b and 4a showed improved cytotoxic activity against MCF-7 cells over amonafide, in particular ...