Medicinal Chemistry Research

New thiazolidinedione-5-acetic acid amide derivatives: synthesis, characterization and investigation of antimicrobial and cytotoxic properties

SG Alegaon, KR Alagawadi

文献索引：Alegaon, Shankar G.; Alagawadi, Kallanagouda R. Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 816 - 824

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被引用次数: 14

摘要

Abstract The present work describes the synthesis, antimicrobial and cytotoxic activity of 2, 4- thiazolidinedione-5-acetic acid amides 3a–n. The structures of the compounds were confirmed by IR, 1 H, 13 C NMR and elemental analysis. All compounds were tested for antimicrobial activity by twofold serial dilution technique. The preliminary results revealed that the compound 3d exhibits promising antibacterial and antifungal activity. The cytotoxic ...