Bromodimethylsulfonium bromide (BDMS)-mediated Lossen rearrangement: synthesis of unsymmetrical ureas

DK Yadav, AK Yadav, VP Srivastava, G Watal…

文献索引：Yadav, Deepak K.; Yadav, Arvind K.; Srivastava, Vishnu P.; Watal, Geeta; Yadav, Lal Dhar S. Tetrahedron Letters, 2012 , vol. 53, # 23 p. 2890 - 2893

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被引用次数: 17

摘要

Bromodimethylsulfonium bromide (BDMS) was found to be a very efficient reagent for Lossen rearrangement of hydroxamic acids to the corresponding isocyanates which were subsequently trapped in situ with various amines to afford unsymmetrical ureas in good to excellent yields (64–89%). The protocol is experimentally simple, mild, and represents valuable alternative to the existing methods for in situ activation of hydroxamic acids ...