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A practical and efficient method for the preparation of sulfonamides utilizing Cl 3 CCN/PPh 3

O Chantarasriwong, DO Jang, W Chavasiri

文献索引：Chantarasriwong, Oraphin; Jang, Doo Ok; Chavasiri, Warinthorn Tetrahedron Letters, 2006 , vol. 47, # 42 p. 7489 - 7492

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被引用次数: 26

摘要

The most commonly used synthetic methods to manipulate sulfonamides involve the nucleophilic attack by ammonia, or primary or secondary amines, with sulfonyl chlorides in the presence of a base. Although this method is efficient, it requires the availability of sulfonyl chlorides, some of which are hard to prepare and difficult to store or handle. Side reactions are also possible due to the presence of base or liberated nucleophilic chloride, particularly under harsh ...