Bollettino della Societa italiana di biologia sperimentale 1980-12-15

[Influence of the chemical structure of aromatic amines on alkaline elution of DNA].

C Bolognesi, C F Cesarone, L Santi

文献索引：Boll. Soc. Ital. Biol. Sper. 56(23) , 2480-5, (1980)

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摘要

The DNA damage induced by in vivo administration of: 2,4-dinitroaniline, ortho-toluidine and para-toluidine, was determined using alkaline filter elution of DNA. The target organs for ultimate carcinogens produced in mice appear to be the liver and the kidney. The damage was evident 4 hours after administration of a single dose of ortho- and para-toluidine. The values obtained after treatment with 2,4-dinitroaniline fall in the range of control mice.