Cutting Long Syntheses Short: Access to Non??Natural Tyrosine Derivatives Employing an Engineered Tyrosine Phenol Lyase

…, K Gruber, F Kaufmann, A Hafner…

文献索引：Seisser, Birgit; Zinkl, Rene; Gruber, Karl; Kaufmann, Franz; Hafner, Andreas; Kroutil, Wolfgang Advanced Synthesis and Catalysis, 2010 , vol. 352, # 4 p. 731 - 736

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被引用次数: 22

摘要

Abstract The chemical synthesis of 3-substituted tyrosine derivatives requires a minimum of four steps to access optically enriched material starting from commercial precursors. Attempting to short-cut the cumbersome chemical synthesis of 3-substituted tyrosine derivatives, a single step biocatalytic approach was identified employing the tyrosine phenol lyase from Citrobacter freundii. The enzyme catalyses the hydrolysis of tyrosine to phenol, ...