Organic letters

Stereoselective Synthesis of Nipecotic Acid Derivatives via Palladium-Catalyzed Decarboxylative Cyclization of γ-Methylidene-δ-valerolactones with Imines

R Shintani, M Murakami, T Hayashi

文献索引：Shintani, Ryo; Murakami, Masataka; Hayashi, Tamio Organic Letters, 2009 , vol. 11, # 2 p. 457 - 459

全文：HTML全文

被引用次数: 31

摘要

A new synthetic method of multisubstituted nipecotic acid (piperidine-3-carboxylic acid) derivatives has been developed by way of palladium-catalyzed decarboxylative cyclization of γ-methylidene-δ-valerolactones with imines. By employing the diethoxyphosphinoyl group as the N-protecting group for imines, the reaction proceeds smoothly with high diastereoselectivity. The products thus obtained can be further derivatized with high ...