Protein Backbone Modification by Novel C. alpha.-C Side-Chain Scission

D Ranganathan, NK Vaish, K Shah

文献索引：Ranganathan; Vaish; Shah Journal of the American Chemical Society, 1994 , vol. 116, # 15 p. 6545 - 6557

被引用次数: 66

摘要

Abstract: a-Ketoamide (-NH-CO-CO-) units in intact peptides are generated from Ser/Thr residues via Ru (VII1)-catalyzed C=-C side-chain scission. Facets associated with this novel a-carbon modification have been probed with 75 peptides chosen to represent every possible peptide environment. The reactions were carried out at room temperature with in situ generated Ru (VII1) in biphasic (CH3CN/CC4/pH 3 phosphate buffer, 1: 1: 2 v/v) ...

1676-81-9

N-苄氧羰基-L-丝氨酸甲酯

~81%

70897-15-3

(S)-(1-氨基-3-羟基-...

~79%

~50%

~11%

~30%

~72%

~60%

~81%

~66%

~82%

~74%

~92%

~92%

~90%

Conversion of serine to stereochemically pure. beta.-substit...

[Arnold; Kalantar; Vederas Journal of the American Chemical Society, 1985 , vol. 107, # 24 p. 7105 - 7109]