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Bioorganic & Medicinal Chemistry 2011-12-15

Synthesis and biological effects of some kynurenic acid analogs

K. Nagy, I. Plangár, B. Tuka, L. Gellért, D. Varga, I. Demeter, T. Farkas, Zs. Kis, M. Marosi, D. Zádori, P. Klivényi, F. Fülöp, I. Szatmári, L. Vécsei, J. Toldi

文献索引:Bioorg. Med. Chem. 19 , 7590-6, (2011)

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摘要

This paper reports the synthesis of 10 new KYNA amides (KYNA-1–KYNA10) and on the effectiveness of this molecule as an inhibitor of excitatory synaptic transmission in the CA1 region of the hippocampus. The most effected molecule is newly synthetized KYNA-analogue (KYNA-1).

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