Effects of solvent and temperature on the 1, 4-asymmetric induction in the diastereoselective hydrogenation of dehydrodipeptides

S Ikeda, T Yamagishi, M Yamaguchi…

文献索引：Ikeda; Yamagishi; Yamaguchi; Hida Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 11 p. 3508 - 3512

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被引用次数: 6

摘要

A study of the effets of solvent and temperature on the stereoselectivity of asymmetric hydrogenation of dehydrodipeptides has been made with Rh (I)–(DPP-AE) catalyst, in which an electrostatic interaction is possible between the dimethylamino group of the ligand and the carboxyl group of the substrate. The highest stereoselectivity was attained in the MeOH– water solvent, while aprotic solvents such as DMF and THF gave comparatively low ...