New synthesis of oxcarbazepine via remote metalation of protected No-tolyl-anthranilamide derivatives

O Lohse, U Beutler, P Fünfschilling, P Furet, J France…

文献索引：Lohse, Olivier; Beutler, Ulrich; Fuenfschilling, Peter; Furet, Pascal; France, Julien; Kaufmann, Daniel; Penn, Gerhard; Zaugg, Werner Tetrahedron Letters, 2001 , vol. 42, # 3 p. 385 - 389

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被引用次数: 37

摘要

Benzyl and allyl protected No-tolyl-anthranilamides were efficiently prepared by Buchwald– Hartwig C–N cross coupling reactions, followed by protection of the amino group. Under directed remote metalation conditions, protected dibenzoazepinones were obtained in good yields. Deprotection of the amine and conversion to an urea furnished a new and efficient synthesis of the antiepileptic drug Trileptal®.