Organic reactions in ionic liquids: N-alkylation of cyclic imides with alkyl halides promoted by potassium fluoride

…, ZC Chen, ZG Le, QG Zheng

文献索引：Hu, Yi; Chen, Zhen-Chu; Le, Zhang-Gao; Zheng, Qin-Guo Journal of Chemical Research, 2004 , # 4 p. 276 - 278

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被引用次数: 9

摘要

Cyclic imide derivatives constitute an important class of chemically, biologically and pharmaceutically significant compounds.1 Despite their wide applicability, available routes for their synthesis are somewhat limited. Generally, most methods involve Lewis acid mediated condensation of an amine with the appropriate cyclic acid anhydrides,1c,2a,2c and cyclisation of the N-substituted amic acid in the presence of acidic reagents.2b Direct N-alkylation under Mitsunobu ...