Quaternary salts of 2-[(hydroxyimino) methyl] imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication
…, GA Koolpe, AB Kelson, HM Vu, DL Taylor…
文献索引：Goff, Dane A.; Koolpe, Gary A.; Kelson, Andrew B.; Vu, Huynh M.; Taylor, Dorris L.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1363 - 1368
A series of quaternary salt derivatives of 2-[(hydroxyimino) methyl]-1-methylimidazole incorporating various side chains bearing ether, silyl, nitrile, ester, halogen, nitro, sulfone, amino, or aminosulfonyl substituents was prepared and evaluated in vivo for the treatment of anticholinesterase intoxication. Test results in the mouse revealed that the type and location of the side-chain substituent both have a significant influence on the toxicity and antidotal ...
