European Journal of Pharmaceutics and Biopharmaceutics 2012-01-01

Thermal degradation of amorphous glibenclamide.

Sönke Rehder, Albrecht Sakmann, Thomas Rades, Claudia S Leopold

文献索引：Eur. J. Pharm. Biopharm. 80(1) , 203-8, (2012)

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摘要

A glibenclamide polymorph published by Panagopoulou-Kaplani and Malamataris (2000) [1], obtained by sublimation of amorphous glibenclamide, was analysed. A new interpretation of the data is presented and experimentally confirmed by X-ray powder diffractometry, Fourier transformation infrared spectroscopy, differential scanning calorimetry, and mass spectrometry. The crystals formed during sublimation of amorphous glibenclamide do not represent a glibenclamide polymorph, but a thermal degradation product, namely 1,3-dicyclohexylurea. The reaction mechanism is suggested to be an elimination of cyclohexylisocyanate from glibenclamide. Cyclohexylisocyanate may decompose to carbon monoxide and cyclohexylamine, which may react in an addition reaction with another cyclohexylisocyanate molecule forming 1,3-dicyclohexylurea.Copyright © 2011. Published by Elsevier B.V.