Novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl) propyl]-1, 2, 4-oxadiazole-5-carboxamides as selective GSK-3 inhibitors

…, EA Katrukha, VI Kazey, I Okun, DV Kravchenko…

文献索引：Koryakova, Angela G.; Ivanenkov, Yan A.; Ryzhova, Elena A.; Bulanova, Elena A.; Karapetian, Ruben N.; Mikitas, Olga V.; Katrukha, Eugeny A.; Kazey, Vasily I.; Okun, Ilya; Kravchenko, Dmitry V.; Lavrovsky, Yan V.; Korzinov, Oleg M.; Ivachtchenko, Alexandre V. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 12 p. 3661 - 3666

全文：HTML全文

被引用次数: 24

摘要

Synthesis, biological evaluation, and SAR dependencies for a series of novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl) propyl]-1, 2, 4-oxadiazole-5- carboxamide inhibitors of GSK-3β kinase are described. The inhibitory activity of the synthesized compounds is highly dependent on the character of substituents in the phenyl ring and the nature of terminal heterocyclic fragment of the core molecular scaffold. The ...