Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4, 6-diazaspiro [2.4] heptane-5, 7-diones

X He, G Qiu, J Yang, Y Xiao, Z Wu, G Qiu…

文献索引：He, Xianran; Qiu, Guanpeng; Yang, Jin; Xiao, Yuling; Wu, Zhongyuan; Qiu, Guofu; Hu, Xianming European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3818 - 3830

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被引用次数: 16

摘要

In the present study on the development of new anticonvulsants, twenty new 6-methyl-1- substituted-4, 6-diazaspiro [2.4] heptane-5, 7-diones were synthesized and tested for anticonvulsant activity using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens. Their neurotoxicity was determined by the rotorod test. In this series, all of the alkyl-and aryl-substituted 5, 5-cyclopropanespirohydantoins ...