Archiv der Pharmazie (Weinheim) 2004-02-01

Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors.

Abed Al-Aziz Al-Quntar, Ofir Baum, Reuven Reich, Morris Srebnik

文献索引：Arch. Pharm. (Weinheim) 337(2) , 76-80, (2004)

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摘要

An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.