A new class of glucosidase inhibitor: Analogues of the naturally occurring glucosidase inhibitor salacinol with different ring heteroatom substituents and acyclic chain …
H Liu, L Sim, DR Rose, BM Pinto
文献索引：Liu, Hui; Sim, Lyann; Rose, David R.; Pinto, B. Mario Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3007 - 3013
Six chain-extended analogues of the naturally occurring glycosidase inhibitor salacinol, with ring-heteroatom variation, were synthesized for structure-activity studies with different glycosidase enzymes. The syntheses involved the reaction of PMB-protected d-and l-seleno- , thio-, and iminoarabinitol with a benzylidene-and isopropylidene-protected 1, 3-cyclic sulfate, derived from commercially available d-sorbitol, in 1, 1, 1, 3, 3, 3-hexafluoro-2- ...
