Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate

NP Grimster, S Connelly, A Baranczak…

文献索引：Journal of the American Chemical Society, , vol. 135, # 15 p. 5656 - 5668

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被引用次数: 29

摘要

... Journal of the ... 2013, 135 (15), pp 5656–5668. DOI: 10.1021/ja311729d. Publication Date (Web): January 25, 2013. Copyright © 2013 American Chemical Society. ... of TTR over its dissociative transition state, and their collective structure–activity relationships allowed us to conceive ...