Synthesis and biological evaluation of nonsymmetrical aromatic disulfides as novel inhibitors of acetohydroxyacid synthase

ZS Li, WM Wang, W Lu, CW Niu, YH Li, ZM Li…

文献索引：Li, Zai-Shun; Wang, Wei-Min; Lu, Wei; Niu, Cong-Wei; Li, Yong-Hong; Li, Zheng-Ming; Wang, Jian-Guo Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3723 - 3727

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被引用次数: 10

摘要

46 Novel nonsymmetrical aromatic disulfides containing [1, 3, 4] thiadiazole or [1, 3, 4] oxadiazole groups were synthesized and their biological activities were evaluated as inhibitors of acetohydroxyacid synthase (AHAS, EC 2.2. 1.6). Besides their strong in vitro inhibition against plant AHAS, compounds 3e and 3f also display 80–100% post-emergence herbicidal activities in greenhouse bioassay at 1500g/ha dosage. The assay of ...