Tetrahedron letters

From isocyanides to trichloropyruvamides: application to a new preparation of oxamide derivatives

L El Kaim, L Gaultier, L Grimaud, E Vieu

文献索引：El Kaim, Laurent; Gaultier, Laetitia; Grimaud, Laurence; Vieu, Emilie Tetrahedron Letters, 2004 , vol. 45, # 43 p. 8047 - 8048

全文：HTML全文

被引用次数: 9

摘要

Since the discovery of the haloform reaction, 1 the trihalomethyl group has been recognized as a potential leaving group in synthesis and its elimination is usually associated with the development of a negative charge at a β-position. This is the case with the formation of isocyanates after basic treatment of N-monoalkyltrichloroacetamides 2 or in the addition–elimination process between amines and trichloromethylketones. 3 Following our studies on trifluoropyruvamides, 4 we ...