Organic letters

Copper-catalyzed CP bond construction via direct coupling of secondary phosphines and phosphites with aryl and vinyl halides

D Gelman, L Jiang, SL Buchwald

文献索引：Gelman, Dmitri; Jiang, Lei; Buchwald, Stephen L. Organic Letters, 2003 , vol. 5, # 13 p. 2315 - 2318

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被引用次数: 217

摘要

A general method for the coupling of aryl and vinyl halides with diaryl and dialkyl phosphines, as well as with dibutyl phosphite, is reported. This highly efficient transformation is realized through the use of copper (I) iodide as a catalyst, N, N'-dimethylethylenediamine as a ligand, and Cs2CO3 as a base. A variety of sterically hindered and/or functionalized substrates were found to react under these reaction conditions to provide products in good ...