Tetrahedron letters

Efficient preparation of imidazo [1, 2-b] pyridazines under Swern oxidative conditions

P Raboisson, B Mekonnen, NP Peet

文献索引：Raboisson, Pierre; Mekonnen, Belew; Peet, Norton P. Tetrahedron Letters, 2003 , vol. 44, # 14 p. 2919 - 2921

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被引用次数: 12

摘要

An efficient synthesis of new imidazo [1, 2-b] pyridazine derivatives was effected by treating 3, 6-dichloropyridazine with various 2-hydroxyethylamines following by imidazole ring formation under Swern oxidative conditions. Some mechanistic aspects of the cyclization step are discussed.