The Journal of organic chemistry

Microbial deracemization of α-substituted carboxylic acids: substrate specificity and mechanistic investigation

D Kato, S Mitsuda, H Ohta

文献索引：Kato, Dai-Ichiro; Mitsuda, Satoshi; Ohta, Hiromichi Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7234 - 7242

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被引用次数: 60

摘要

A new enzymatic method for the preparation of optically active α-substituted carboxylic acids is reported. This technique is called deracemization reaction, which provides us with a route to obtain the enantiomerically pure compounds, theoretically in 100% yield starting from the racemic mixture. This means that the synthesis of a racemate is almost equal to the synthesis of the optically active compound, and this concept is entirely different from the ...