Tetrahedron Letters

Cleavage of the THP protecting group under Pd/C-catalyzed hydrogenation conditions

LH Kaisalo, TA Hase

文献索引：Kaisalo, Leena; Hase, Tapio Tetrahedron Letters, 2001 , vol. 42, # 43 p. 7699 - 7701

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被引用次数: 15

摘要

Alcohol and phenol THP or ethoxyethyl ether protecting groups may be cleaved in high yield under Pd/C-catalyzed hydrogenation conditions in EtOH, owing to the inadvertent presence of small quantities of HCl in the reaction mixture. MOM ethers are not cleaved under these conditions.