Synthetic study of (+)-nootkatone from (-)-. beta.-pinene

…, M Miyashita, A Yoshikoshi

文献索引：Yanami, Tetsuji; Miyashita, Masaaki; Yoshikoshi, Akira Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 607 - 612

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被引用次数: 52

摘要

A facile stereoselective synthesis of (+)-nootkatone (1) has been achieved starting with (+)- nopinone (2b). The key step was the conjugate addition of methallyltrimethylsilane (20b) to trans-3-ethylidenenopinone (16), which was obtainable from 2b on the cross condensation with acetaldehyde followed by acid treatment, giving an adduct with the desired stereochemistry, 24a, as the predominant product. Dione 23, obtained from the adduct on ...

4674-50-4

努特卡酮, 诺卡酮

~81%

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