Journal of Organic Chemistry 2011-05-20

Xanthone natural products via N-heterocyclic carbene catalysis: total synthesis of atroviridin.

Yumiko Suzuki, Yoshinori Fukuta, Shinya Ota, Masayo Kamiya, Masayuki Sato

文献索引：J. Org. Chem. 76(10) , 3960-7, (2011)

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摘要

The total synthesis of atroviridin has been accomplished by a linear route involving the N-heterocyclic carbene (NHC)-catalyzed aroylation of the fluorobenzene derivative, Claisen cyclization of the O-propargylated benzophenones, and intramolecular 1,4-addition of the quinone intermediates. The result provides a viable route to xanthone natural products.