Identification of 5, 6-substituted 4-aminothieno [2, 3-d] pyrimidines as LIMK1 inhibitors

BE Sleebs, G Nikolakopoulos, IP Street, H Falk…

文献索引：Sleebs, Brad E.; Nikolakopoulos, George; Street, Ian P.; Falk, Hendrik; Baell, Jonathan B. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5992 - 5994

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被引用次数: 15

摘要

4-Aminobenzothieno [3, 2-d] pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5, 6-substituted 4-aminothieno [2, 3-d] pyrimidines with low micromolar inhibition of LIMK1.