Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2, 4-dihydro-1H-benzo [b][1, 2, 4] triazolo [4, 3-d][1, 4] thiazin-1-ones in various murine experimental …

…, SB Wang, XQ Deng, DC Liu, ZS Quan

文献索引：Cao, Xu; Wang, Shi-Ben; Deng, Xian-Qing; Liu, Da-Chuan; Quan, Zhe-Shan Medicinal Chemistry Research, 2014 , vol. 23, # 4 p. 1829 - 1838

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摘要

Abstract A novel series of 7-alkoxy-2, 4-dihydro-1 H-benzo [b][1, 2, 4] triazolo [4, 3-d][1, 4]- thiazin-1-ones have been synthesized and tested for their anticonvulsant activity using the maximal electroshock (MES) method. The majority of the compounds prepared were effective in the MES screens at a dose level of 100 mg/kg. Of the compounds tested, the most promising was 7-[(4-fluorobenzyl) oxy]-2, 4-dihydro-1 H-[1, 2, 4]-triazolo [4, 3-d][1, 4]- ...