Journal of Physical Chemistry B 2010-12-16

Femtosecond dynamics of a porphyrin derivative confined by the human serum albumin protein.

Anna Synak, Marcin Ziołek, Juan Angel Organero, Abderrazzak Douhal

文献索引：J. Phys. Chem. B 114(49) , 16567-73, (2010)

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摘要

The relaxation dynamics of 5,10,15,20-tetrakis(4-hydroxyphenyl)-porphyrin (p-THPP) in tetrahydrofuran (THF) and encapsulated within the human serum albumin (HSA) protein in water solution was investigated. The protein environment affects the B→Q(y) and Q(x)→Q(y) transition dynamics (from 80 and 140-200 fs in THF to 50 and 100 fs in HSA, respectively) as well as the lifetime of the relaxed Q(x) state (9.1 vs 9.9 ns). The most prominent differences are observed in the relaxation dynamics in the hot Q(x) state in HSA, which includes the energy transfer to the protein in ∼1 ps and much slower solvent-assisted thermal equilibration component of about 20-30 ps.