Incorporation of a 3-(2, 2, 2-trifluoroethyl)-γ-hydroxy-γ-lactam motif in the side chain of 4-aminoquinolines. Syntheses and antimalarial activities

D Cornut, H Lemoine, O Kanishchev…

文献索引：Cornut, Damien; Lemoine, Hugues; Kanishchev, Oleksandr; Okada, Etsuji; Albrieux, Florian; Beavogui, Abdoul Habib; Bienvenu, Anne-Lise; Picot, Stephane; Bouillon, Jean-Philippe; Medebielle, Maurice Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 73 - 83

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被引用次数: 31

摘要

In this paper we report the synthesis and antimalarial properties of two series of fluoroalkylated γ-lactams derived from 4-aminoquinoline as potent chemotherapeutic agents for malaria treatment. These molecules obtained in several steps resulted in the identification of very potent structures with in vitro activity against Plasmodium falciparum clones of variable sensitivity (3D7 and W2) in the range of 19–50 nM with resistance ...