A 64-year-old female patient developed periorbital eczema after eye treatment with a corticoid ointment. Epicutaneous tests with the effective component as well as with other ingredients of the ointment and suspected substances revealed a delayed hypersensitivity to prednisolone-21-trimethyl acetate, neomycin, cobalt, and cetyl alcohol. We did not observe any cross-reactions to other corticoids, not even to the closely related prednisolone-21-monoacetate. To the best of our knowledge, allergic contact dermatitis to prednisolone-21-trimethyl acetate has not been described in the literature so far.
