Investigation of structure–activity relationships in a series of glibenclamide analogues

E Yuriev, DCM Kong, MN Iskander

文献索引：Yuriev, Elizabeth; Kong, David C.M.; Iskander, Magdy N. European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 835 - 847

全文：HTML全文

被引用次数: 22

摘要

In this study, the synthesis of 15 new glibenclamide analogues is described. The conformational trends of these analogues were investigated using Monte Carlo conformational analysis. The conformational analysis results resolved the discrepancy between previous molecular modelling simulations of glibenclamide and allowed rationalizing the effect of aqueous environment on the overall conformation. The 3D- ...