Journal of the American Chemical Society 2012-07-25

Palladium-catalyzed, asymmetric Mizoroki-Heck reaction of benzylic electrophiles using phosphoramidites as chiral ligands.

Zhigang Yang, Jianrong Zhou

文献索引：J. Am. Chem. Soc. 134(29) , 11833-5, (2012)

全文：HTML全文

摘要

We report herein the first examples of asymmetric Mizoroki-Heck reactions using benzyl electrophiles. A new phosphoramidite was identified to be an effective chiral ligand in the palladium-catalyzed reaction. The reaction is compatible with polar functional groups and can be readily scaled up. Several cyclic olefins worked well as olefin components. Thirty-one examples are included.