New chemoenzymatic pathway for β-adrenergic blocking agents

A Kamal, GBR Khanna, T Krishnaji, V Tekumalla…

文献索引：Kamal, Ahmed; Khanna, G.B. Ramesh; Krishnaji; Tekumalla, Venkatesh; Ramu Tetrahedron Asymmetry, 2005 , vol. 16, # 8 p. 1485 - 1494

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被引用次数: 23

摘要

The lipase mediated kinetic resolution of pharmaceutically important β-hydroxy nitriles is described in high enantiomeric excesses and good yields. Some of the chiral β-hydroxy nitriles have been employed in the synthesis of β-adrenergic blocking agents such as ...