A new synthesis of temozolomide

MJ Wanner, GJ Koomen

文献索引：Wanner, Martin J.; Koomen, Gerrit-Jan Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 16 p. 1877 - 1880

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被引用次数: 9

摘要

An efficient condensation reaction between nitrosoimidazoles and phenyl methylcarbazate forms the basis of a new synthetic route to phenyloxycarbonyl substituted triazenylimidazoles. Exposure of these triazenes to diffuse daylight is sufficient to induce (E) to (Z)-isomerization of the triazene–NN–bond, resulting in spontaneous formation of temozolomide in high yield.