Potential neuroleptics of the orthopramide series; synthesis of heterocyclic 5-amino-2-methoxybenzamides and of some related compounds

…, J Holubek, E Svátek, O Matoušová…

文献索引：Valenta, Vladimir; Holubek, Jiri; Svatek, Emil; Matousova, Oluse; Metysova, Jirina; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, p. 1297 - 1310

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被引用次数: 4

摘要

Abstract 2-Methoxy-5-nitrobenzoyl chloride was reacted with 2-(aminomethyl)-1- ethylpyrrolidine, 3-amino-1-ethylpiperidine, 4-amino-1-benzylpiperidine, 1- benzylpiperazine, and 1-amino-4-benzylpiperazine and gave the N-substituted 2-methoxy-5- nitrobenzamides VIa-VIe. Their reduction with hydrazine hydrate and Raney nickel in ethanol afforded the corresponding 5-amino-2-methoxybenzamides VIIa-VIIe. The amino ...