Tetrahedron letters

One carbon homologation of halides to benzyl ethers

DF Taber, CM Paquette, PG Reddy

文献索引：Taber, Douglass F.; Paquette, Craig M.; Reddy, P. Ganapati Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2462 - 2463

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被引用次数: 4

摘要

Often in organic synthesis, removing unwanted steps in a synthetic route is convenient from both a time and material standpoint. Adding a step for protection of an alcohol after homologation can be circumvented by the approach presented here. This reduces both the time and the solvent costs needed to purify products, minimizing waste. ... As the starting point for a total synthesis, we needed the benzyl ether 2a. Although a multi-step preparation had been ...