Rapid and convenient thermal or microwave-assisted synthesis of substituted 2-phenylbenzothiazoles

…, MC Dix, MC Bagley, AD Westwell

文献索引：Weekes, Ashley A.; Dix, Matthew C.; Bagley, Mark C.; Westwell, Andrew D. Synthetic Communications, 2010 , vol. 40, # 20 p. 3027 - 3032

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被引用次数: 9

摘要

A simple one-step method for the synthesis of biologically relevant 2-phenylbenzothiazoles has been developed, using sodium metabisulfite as an oxidant following condensation between 2-aminothiophenol and substituted benzaldehydes. Attractive features of this new method include excellent yields under both microwave-assisted or thermal conditions (it is tolerant of a variety of substituents on the phenyl ring) and simple product isolation without ...