… and antiproliferative properties of N 3/8-disubstituted 3, 8-diazabicyclo [3.2. 1] octane analogues of 3, 8-bis [2-(3, 4, 5-trimethoxyphenyl) pyridin-4-yl] methyl-piperazine

R Filosa, A Peduto, P De Caprariis, C Saturnino…

文献索引：Filosa, Rosanna; Peduto, Antonella; de Caprariis, Paolo; Saturnino, Carmela; Festa, Michela; Petrella, Antonello; Pau, Amedeo; Pinna, Gerard Aime; La Colla, Paolo; Busonera, Bernardetta; Loddo, Roberta European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 293 - 306

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被引用次数: 27

摘要

A series of novel N3/8-disubstituted-3, 8-diazabicyclo [3.2. 1] octanes in order to improve the in vitro activity of the prototype 3, 8-bis [2-(3, 4, 5-trimethoxyphenyl) pyridyl-4-yl) methylpiperazine (1) were synthesized and evaluated by assays of growth inhibition against several tumor cell lines. Compounds 2a, b, f and m demonstrated not only growth-inhibitory activities against leukemia cancer cells, but also fairly good activities against the growth of ...