Chemistry: A European Journal 2013-07-29

Highly efficient catalytic enantioselective Mannich reaction of malonates with N-tert-butoxycarbonyl imines by using Yb(OTf)3/pybox catalysts at room temperature.

Babak Karimi, Ehsan Jafari, Dieter Enders

文献索引：Chemistry 19(31) , 10142-5, (2013)

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摘要

Go Mannich! A highly efficient and enantioselective method for the direct asymmetric reaction of dibenzyl malonate with N-tert-butoxycarbonyl aldimines in the presence of Yb(OTf)3 and iPr-pybox complexes is described (see scheme; pybox = pyridine bisoxazoline).Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.